The population was 525 at the 2010 census.
Parryville is located in southern Carbon County at 40°49′28″N 75°40′9″W (40.824403, -75.669246), along Pohopoco Creek just north of its confluence with the Lehigh River. Interstate 476 (the Northeast Extension of the Pennsylvania Turnpike) passes through the western part of the borough, with access from Exit 74 (U.S. Route 209) just north of the borough limits. I-476 leads south 20 miles (32 km) to the Allentown area and north 50 miles (80 km) to Scranton.
According to the United States Census Bureau, Parryville has a total area of 1.63 square miles (4.22 km2), of which 1.61 square miles (4.17 km2) is land and 0.02 square miles (0.04 km2), or 1.03%, is water.
As of the census of 2000, there were 478 people, 189 households, and 140 families residing in the borough. The population density was 293.2 people per square mile (113.2/km²). There were 222 housing units at an average density of 136.2 per square mile (52.6/km²). The racial makeup of the borough was 98.74% White, 0.21% African American, 0.42% Native American, 0.21% from other races, and 0.42% from two or more races. Hispanic or Latino of any race were 0.21% of the population.
There were 189 households, out of which 23.8% had children under the age of 18 living with them, 62.4% were married couples living together, 6.9% had a female householder with no husband present, and 25.9% were non-families. 19.6% of all households were made up of individuals, and 9.5% had someone living alone who was 65 years of age or older. The average household size was 2.53 and the average family size was 2.91.
In the borough the population was spread out, with 18.8% under the age of 18, 7.9% from 18 to 24, 29.5% from 25 to 44, 28.9% from 45 to 64, and 14.9% who were 65 years of age or older. The median age was 41 years. For every 100 females there were 108.7 males. For every 100 females age 18 and over, there were 112.0 males.
The median income for a household in the borough was $33,958, and the median income for a family was $37,917. Males had a median income of $28,409 versus $19,688 for females. The per capita income for the borough was $15,409. About 1.6% of families and 6.2% of the population were below the poverty line, including none of those under age 18 and 19.3% of those age 65 or over.